GLP-2 (Glucagon-Like Peptide-2) is a 33-amino acid peptide hormone secreted by intestinal L-cells alongside GLP-1. Unlike its metabolic counterpart, GLP-2 specifically targets the gastrointestinal tract, making it uniquely valuable for intestinal research.
Mechanism of Action:
GLP-2 binds to GLP-2 receptors (GLP-2R) expressed on enteric neurons and subepithelial myofibroblasts. This triggers downstream signaling that:
• Stimulates crypt cell proliferation
• Inhibits enterocyte apoptosis
• Enhances intestinal barrier function
• Increases mesenteric blood flow
• Upregulates nutrient transporter expression
Research Significance:
GLP-2 and its analogues are studied for short bowel syndrome, inflammatory bowel disease, intestinal failure, and chemotherapy-induced mucositis. The peptide’s intestinotrophic effects make it valuable for intestinal adaptation research.
Technical Specifications:
• Sequence: 33 amino acids
• Molecular Weight: ~3766 g/mol
• Purity: >98% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C, protect from light
• Half-life: ~7 minutes (native form)
For research purposes only. Not for human consumption.